The Mexico Documents Collection contains 162 documents (personal and official correspondence, government orders, decrees, pamphlets, and government announcements), varying from a parchment document with elaborate signature to official typed decrees from the Office of the President. Chronicling Mexico from 1570-1913, the collection spans four distinct periods of Mexican history: the Colonial Period, Mexican Independence, the Mexican-American War, and the Mexican Revolution.

A large portion of the collection is from the years between Mexican Independence (1821) and the end of the Mexican-American War (1849). Nearly all of the items are in Spanish but many have accompanying English translations. Notable individuals found in the collection include Mexican Presidents, Santa Anna de Lopez and Porfirio Diaz, and Jose Joaquin de Hererra. Additionally, some materials document American military actions in Mexico during the Mexican-American War. Lastly, there are an assortment of documents chronicling religion in Mexico as well as business and land transactions.

The original materials are available in UH Libraries' Special Collections in the Mexico Documents Collection.